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Pregnancy and breast-feeding: Melatonin is POSSIBLY UNSAFE when taken by mouth or injected into the body during pregnancy. Melatonin might also interfere with ovulation, making it more difficult to become pregnant. Not enough is known about the safety of using melatonin when breast-feeding. Children: Melatonin is POSSIBLY SAFE when taken by mouth as a single dose. Faigl, V., Keresztes, M., Kulcsar, M., Nagy, S., Keresztes, Z., Amiridis, G. Testicular function and semen characteristics of Awassi rams treated with melatonin out of the breeding season. Bleeding disorders: Melatonin might make bleeding worse in people with bleeding disorders. Depression: Melatonin can make symptoms of depression worse. Etzioni, A., Luboshitzky, R., Tiosano, D., Ben Harush, M., Goldsher, D., and Lavie, P. High blood pressure: Melatonin can raise blood pressure in people who are taking certain medications to control blood pressure. Seizure disorders: Using melatonin might increase the risk of having a seizure. Esteban, S., Garau, C., Aparicio, S., Moranta, D., Barcelo, P., Fiol, M. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. Transplant recipients: Melatonin can increase immune function and might interfere with immunosuppressive therapy used by people receiving transplants. Effect of melatonin on serum cholesterol and phospholipid levels, and on prolactin, thyroid-stimulating hormone and thyroid hormone levels, in hyperprolactinemic rats. Melatonin's main job in the body is to regulate night and day cycles or sleep-wake cycles. Darkness causes the body to produce more melatonin, which signals the body to prepare for sleep. Epileptogenic action of intraventricularly injected antimelatonin antibody.

Melatonin used as medicine is usually made synthetically in a laboratory. It is also used to calm people before they are given anesthesia for surgery. The forms of melatonin that can be absorbed through the cheek or under the tongue are used for insomnia, shift-work disorder, and to calm people before receiving anesthesia for surgery. [Role of melatonin in spatial learning and memory in rats and its mechanism]. Melatonin is POSSIBLY SAFE when used by mouth appropriately, long-term. Melatonin has been used safely for up to 2 years in some people.

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